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This is plain-language harm-reduction information, not medical advice. Peptides discussed here are research compounds; most are not approved for human use. People will use them either way — we would rather they have the facts.
What it is
Kisspeptin sits at the very top of the reproductive hormone cascade. When it is released in the brain, it tells the hypothalamus to release GnRH, which tells the pituitary to release LH, which tells the testes to make testosterone (or the ovaries to do their thing).
Kisspeptin-10 is the active 10-amino-acid fragment used in research and grey-market protocols.
History
Discovered in 1996, originally as a tumour suppressor gene (KISS1) before its reproductive role was understood. Reproductive function role nailed down in the early 2000s.
How it works
Activates the KISS1R receptor in the hypothalamus, triggering GnRH release and the downstream HPG axis.
Dosage
- 50–200 mcg subcutaneously, 1–3 times daily as needed.
- Some research protocols use continuous infusion — not practical at home.
How it is taken
- Subcutaneous injection.
How to reconstitute
- 5 mg vial with 2 ml BAC water = 2.5 mg/ml. 100 mcg = 4 units on a 1 ml insulin syringe.
How it should arrive
White powder, sealed vial.
How it should look once reconstituted
Clear colourless solution.
What to expect, and when
- Acute hormonal effect (LH and testosterone bump): within 1–2 hours of dosing.
- Subjective wellbeing / libido effects: minutes to hours.
Side effects
- Generally well tolerated.
- Some users report transient headaches.
Risks
- Mostly acute, short-lived effect. Long-term repeated stimulation of the axis has been less studied.
- Continuous stimulation desensitises the receptor; pulsed dosing matters.
Potential gains
- Short-term boost in endogenous testosterone production.
- Increased libido.
- Useful in PCT or recovery contexts to encourage HPG axis function.
Other useful information
A research peptide more than a daily-driver. Most useful in specific hormonal-recovery contexts.
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