Hexarelin

What it is

Hexarelin is the most potent GHRP per mcg, but the trade-off is that it raises cortisol and prolactin and your pituitary desensitises to it faster than with ipamorelin.

Used for short cycles by people prioritising GH spike over a clean side-effect profile.

History

Developed in the 1990s as part of the GHRP family research. Investigated for short-stature treatment but never approved as a medicine.

How it works

Same ghrelin-receptor mechanism as other GHRPs, but binds more strongly. Also has some cardiac-tissue activity that other GHRPs lack.

Dosage

• Typical: 100 mcg, 1–3 times daily.
• Limit to 6–8 week cycles — pituitary desensitisation is real.
• Often paired with a GHRH analogue.

How it is taken

• Subcutaneous injection.

How to reconstitute

• 5 mg vial with 2 ml BAC water = 2.5 mg/ml. 100 mcg = 4 units on a 1 ml insulin syringe.

How it should arrive

White powder, vacuum-sealed vial.

How it should look once reconstituted

Clear colourless solution.

What to expect, and when

• GH-driven effects similar timeline to ipamorelin.
• Pituitary tolerance noticeable after 6–8 weeks of daily use.

Side effects

• Stronger flushing/head rush than ipamorelin.
• Elevated cortisol and prolactin.
• Hunger increase.
• Lethargy at higher doses.

Risks

• Pituitary desensitisation faster than other GHRPs.
• Theoretical cardiac effects (mostly considered positive in research but unproven in humans).
• WADA prohibited.

Potential gains

• Largest GH spike per dose.
• Some research interest in cardiac protective effects.

Other useful information

A more aggressive choice than ipamorelin. Most users prefer ipamorelin's cleaner profile unless they specifically want the bigger spike for short cycles.