CJC-1295 + Ipamorelin blend

What it is

This is a pre-mixed vial of two growth hormone secretagogues: CJC-1295 without DAC (a GHRH analogue, also called modified GRF 1-29) and ipamorelin (a ghrelin-receptor agonist, or GHRP). Both prompt your pituitary to release your own growth hormone, through two different receptors, and the idea is that using them together produces a bigger pulse than either alone.

Our vial is 10 mg: 5 mg CJC-1295 (without DAC) and 5 mg ipamorelin. This is the most commonly used GH peptide stack in the community. The synergy between a GHRH and a GHRP is real in physiology studies, but this specific blend has not been trialled, and neither peptide is an approved medicine.

History

CJC-1295 was developed by ConjuChem in the early 2000s; the non-DAC form is a modified version of a shorter GHRH fragment. Ipamorelin was developed by Novo Nordisk in the late 1990s as a more selective GHRP. Neither reached approval as a medicine. The pairing became a community standard in the 2010s.

How it works

CJC-1295 binds the GHRH receptor and ipamorelin binds the ghrelin receptor, both on pituitary cells. Activating both together gives a synergistic GH pulse. Both are short-acting, so each injection gives a single pulse rather than constant elevation. That is closer to your natural rhythm than injecting growth hormone itself, and is the main reason people choose them.

Dosage

• A commonly reported range is 100-300 mcg of each peptide per injection, once to three times daily. Equal amounts of each is the norm, which matches the 1:1 blend.
• Most people inject before bed (on an empty stomach, as food and insulin blunt the response) and sometimes also on waking. Typical courses are 8-12 weeks, followed by a break.
• These ranges come from community use and physiology studies of the individual peptides, not trials of this blend.
• Because the ratio is fixed, you cannot adjust one without the other.

How it is taken

• Subcutaneous injection into belly fat with a 29-31G insulin syringe.
• Inject 2-3 hours after your last meal, or fasted, because high blood sugar and insulin blunt GH release.
• Rotate injection sites.

How to reconstitute

• For the 10 mg vial (5 mg CJC-1295 + 5 mg ipamorelin), add 2 ml bacteriostatic water. That gives 5 mg/ml total, or 2.5 mg/ml (2,500 mcg/ml) of each.
• On a 1 ml / 100-unit syringe, 4 units (0.04 ml) = 100 mcg of each. 10 units (0.1 ml) = 250 mcg of each. 12 units = 300 mcg of each.
• Always work from the amounts on your own vial's label.
• Add the water slowly down the inside wall. Swirl gently. Do not shake.

How it should arrive

Sealed glass vial with an intact crimped cap and a white to off-white powder cake. Neither peptide is coloured, so the powder should be white.

How it should look once reconstituted

A clear, colourless solution with no cloudiness, flecks or residue.

What to expect, and when

• Sleep quality changes: some people report deeper sleep and vivid dreams within the first 1-2 weeks.
• Recovery and body composition changes: realistically 6-12 weeks, if any.
• IGF-1 (a blood marker of GH activity) can be tested to see whether anything is happening; subjective effects are unreliable.

Side effects

• Flushing, warmth or a head-rush within minutes of injecting (usually attributed to CJC-1295).
• Headache, dizziness and nausea.
• Water retention, pins and needles or numb hands (carpal-tunnel-type symptoms) as GH rises.
• Increased hunger can occur, though ipamorelin is less prone to it than other GHRPs.
• Injection-site redness or itching.

Risks

• No human trial data exists for this combination, and neither peptide is an approved medicine.
• Raising GH and IGF-1 has theoretical risks, including insulin resistance and higher blood sugar, fluid retention, and possible stimulation of existing tumours. If you have diabetes, a cancer history or a suspected tumour, this is a reason to avoid it.
• Long-term effects of chronically raised GH and IGF-1 from secretagogues are not known.
• Quality varies. A two-peptide blend can be under-dosed in one component and still look right. Third-party testing is the only real check.
• Both are banned for competitive athletes under WADA rules.

Potential gains

• Higher natural GH pulses, shown in physiology studies of the individual peptides.
• Reported benefits include better sleep, recovery, fat loss and skin quality. Evidence for these is mostly anecdotal, not from trials of this stack.
• Convenience: one vial and one injection.

Other useful information

The 1:1 ratio is close to what most people already use, so a fixed blend costs little in flexibility. If you want to alter the ratio, you need separate vials. Do not confuse this with CJC-1295 DAC, the long-acting form, which is a different product with a different dosing pattern. Check your label says 'no DAC'.